Creatine is the most thoroughly researched supplement in human history — and the most overlooked compound in the cognitive enhancement space. The Rae et al. trial found significant improvements in working memory and fluid intelligence. The McMorris research found it protects cognitive function under sleep deprivation. After 18+ years of research, here is the complete evidence-based guide to the brain energy compound that completes the advanced protocol.

Caffeine and L-theanine is the most referenced stack in this series — and the most under-explained. After 18+ years of research and multiple neuroimaging trials confirming genuine synergistic effects, here is the complete evidence-based guide: how the combination works, what the Haskell and Foxe studies actually showed, the 1:2 ratio protocol, and the tolerance management framework that makes it sustainable.

Phosphatidylserine is the only nootropic compound with an FDA qualified health claim for cognitive function — a regulatory distinction every serious cognitive enhancement researcher should understand. After 18+ years of research and a trial reversing 12 years of age-related cognitive decline, here is the complete evidence-based guide to the compound that holds the advanced stack together at the structural level.

Alpha-GPC is a pharmaceutical compound approved by prescription in Europe that most people treat like a casual supplement. After 18+ years of research and a 2,044-patient clinical trial, here is the complete evidence-based guide — how it works, what the research actually shows, the TMAO cardiovascular consideration every user needs to understand, and the cholinergic stack that makes it most powerful.

Most people take Rhodiola expecting it to feel like caffeine — and conclude it doesn’t work when it doesn’t. After 18+ years of research and multiple clinical trials, here is what Rhodiola actually does, why it matters more than stimulants for real-world cognitive performance, and the exact dose and timing the evidence supports.

Bacopa Monnieri has a meta-analysis of nine randomized controlled trials behind it — and still most people quit before it works. After 18+ years of research, here is the complete evidence-based guide: how it works, what the research actually shows, the exact dose to use, and why patience is not optional with this compound.

Most people asking whether nootropics are safe are actually asking the wrong question. After 18+ years of research, here is the honest evidence-based answer — compound by compound safety profiles, the individual risk factors that actually matter, and the red flags that should stop you from buying a product entirely.